Health care associated infections (HCAIs) and the associated antimicrobial resistance (AMR) is a major global public health problem causing increased hospital stay, cost of therapy and mortality. The impact of HCAIs and antimicrobial resistance is much higher for developing countries because of limited resources, healthcare infrastructure and competence. The main objective of this project was to develop competence of healthcare staffs and increase the awareness through capacity building for prevention of HCAIs and antimicrobial resistance in Ethiopia.