The publication provides a summary on the state of the climate indicators in 2021 including global temperatures trends and its distribution around the globe; most recent finding on Green House Gases concentration, Ocean indicators; Cryosphere with a particular emphasis on Arctic and Antarctic sea ice, greenland ice sheet and glaciers and snow cover; Stratospheric Ozone; analysis of major drivers of inter-annual climate variability during the year including the El Niño Souther Oscillation and other Ocean and Atmshperic indices; global precipitation distribution over land; extreme events including those related to tropical cyclones and wind storms; flooding, drought and extreme heat and cold events. The publication also provides most recent finding on climate related risks and impacts including on food security, humanitarian and population displacement aspects and impact on ecosystems.