Firefighting is by its very nature an occupation of considerable risk and potential danger. As a part of the United States Fire Administration’s Major Fires Investigation Project, this special report has been produced to help inform firefighters of the particular danger of fires in agricultural silos and the hazards that may be encountered in fire operations in and around these structures. Silo fires and explosions have been responsible for the deaths and injuries of firefighters and civilians. Since 1985, at least six firefighters have been killed in silo emergencies; three were killed in a silo fire explosion in Ohio, two in a different silo explosion in Georgia, and another was asphyxiated in a grain storage facility in Iowa. The lethal potential is also underscored by the fact that many civilian workers have lost their lives in non-fire situations in grain or silage storage facilities. Some silo emergencies can be immediately life threatening and all can be dangerous to firefighters if appropriate safety precautions are not followed. This special report is meant to provide information to prepare for and safely extinguish fires in agricultural silos.