The DASA-AEC-Lovelace Foundation Blast-Simulation Facility for the biomedical investigation of the effects of Blast and Shock is described in detail. Photographs, descriptions, and specifications of four air-driven shock tubes, ranging from 12 to 72 in. in diameter, and a concrete-pad, high-explosive test site are given. The instrumentation system and shock-tube and gauge-calibration procedures are included. Test parameters for each shock tube are briefly summarized and supported by pressure-time patterns and calibration curves.